Interventional cardiology × engineering

Publications& research.

Making the device fit the vessel.
Connecting clinical questions with engineering.

Lingsen You

Lingsen (Lucas) You 游凌森 · M.D., Ph.D.
Zhongshan Hospital, Fudan University

DEVICE–VESSEL SUITCORDANCE · AI & DIGITAL TWINS · PANVASCULAR PLATFORMS

A connected view
of vascular care.

I am an interventional cardiologist and researcher at Zhongshan Hospital, Fudan University, and an executive committee member of the Center of Cardiovascular Innovation of China (CCI). My work connects vascular biology, medical devices, flexible electronics, intravascular imaging, artificial intelligence and digital twins.

游凌森(Lingsen You / Lucas You),复旦大学附属中山医院介入心脏病学医生与研究者。研究围绕器械–血管适配(device–vessel suitcordance)与泛血管介入展开,结合柔性电子、血管内成像、人工智能与数字孪生,探索监测、干预和评估的一体化方法。下方收录相关论文、作者顺序、期刊影响因子与原文链接。

01 / The framework

Device–vessel suitcordance

A translational framework for matching interventions with vessel anatomy, haemodynamics, biology and time.

02 / Adaptive decisions

AI & digital twins

Intravascular imaging, intelligent photonics and patient-specific modelling for more adaptive vascular care.

03 / Across scales

Panvascular platforms

Flexible electronics, intelligent fibres and organ-on-chip systems connecting sensing, intervention and evaluation.

Selected publications

2025–2026 · Publications & research

9 selected works · 8 published papers and 1 accepted manuscript

IF = journal impact factor. Year and source are shown on each badge. Trends in Molecular Medicine retains the supplied site record.

2026

06 WORKS / INCLUDING ONE ACCEPTED MANUSCRIPT
A river in balance, annotated with the three ecological balances of vascular-device suitcordance: mechanical, cellular and physicochemical-immune
Trends in Molecular MedicineCell Press journal
IF 18.12025 · site record

Vascular-Device Suitcordance: A Tri-Ecological Framework for Eco-Rebalancing

Lingsen You, …, Junbo Ge

An ecological framework for considering how vascular devices interact with mechanical, cellular and physicochemical-immune balance over time.

Accepted 14 September 2026
Accepted · In production
DOI to follow

2025 World-Class Sci-Tech Journal

Kaplan-Meier curves of in-hospital all-cause mortality with and without intra-aortic balloon pump support in the sIPTW-weighted cohort
Biomarker ResearchLarge-scale nationwide cohort37,477 patients · China Chest Pain Center Database
IF 14.62025 JIF

Intra-aortic balloon pump use and in-hospital mortality in acute myocardial infarction with Killip class III or IV: a nationwide cohort study

Lingsen You, Hao Li, Zhenzhen Lu, Yu Wang, Shanyuan Hong, Mengyao Wang, Tongtong Zang, Lihong Huang, Li Shen, Junbo Ge

A nationwide cohort of 37,477 patients undergoing PCI for acute myocardial infarction with Killip class III or IV, drawn from the China Chest Pain Center Database (4,089 hospitals, 2019–2023). Using target-trial emulation with BART-based stabilised inverse probability weighting, intra-aortic balloon pump use during hospitalisation was associated with higher in-hospital all-cause mortality (28.1% vs. 19.1%; HR 1.48, 95% CI 1.37–1.61).

26 August 2026 · 14:97
DOI: 10.1186/s40364-026-00993-1

2025 World-Class Sci-Tech Journal

Light: Science & Applications, Intelligent Photonics and Digital Twins in Panvascular Disease
Light: Science & ApplicationsNature Portfolio journalReview
IF 24.02025 JIF

From intravascular imaging to adaptive vascular care: intelligent photonics and digital twins in panvascular disease

Lingsen You, Jiaxin Yao, Yaoqing Qiu, Yu Wang, Yunlu Sun, Rongjun Zhang, Li Shen, Junbo Ge

A review connecting intravascular optical imaging, AI-based image analysis and image-derived digital twins through the lens of device-vessel suitcordance.

4 August 2026 · 15:335
DOI: 10.1038/s41377-026-02410-6

2025 World-Class Sci-Tech Journal

The FLOW Framework panvascular-on-a-chip platform
Science BulletinConceptual framework
IF 21.12025 JIF

The FLOW Framework: a panvascular-on-a-chip platform to model systemic disease and guide panvascular interventional device suitcordance

Lingsen You, Yuheng Chen, Zeyang Zhang, Yu Wang, Zhongze Gu, Li Shen, Junbo Ge

A panvascular-on-a-chip framework for exploring systemic vascular disease and device-vessel interactions across distinct vascular environments.

February 2026 issue · Online 31 December 2025
DOI: 10.1016/j.scib.2025.12.051

2025 World-Class Sci-Tech Journal

2025

03 PUBLISHED PAPERS
Advanced Fiber Materials, Volume 7 Issue 4 front cover featuring High-Suitcordance Intelligent Fibers for Panvascular Disease Monitoring-Intervention
Advanced Fiber Materials · Front cover
Advanced Fiber MaterialsReview
IF 22.62025 JIF

High-Suitcordance Intelligent Fibers for Panvascular Disease Monitoring-Intervention

Lingsen You, Yuchen Luo, Qiang Cheng, Li Shen, Junbo Ge

A review of flexible fibre systems for panvascular monitoring and intervention, with suitcordance linking immediate suitability to longer-term biological demands.

2024–2025 Best Cover Article Award

8 May 2025
DOI: 10.1007/s42765-025-00542-9

2025 World-Class Sci-Tech Journal

The 2025 World-Class Sci-Tech Journal label refers to the ISTIC directory released in September 2026. The Trends in Molecular Medicine manuscript was accepted on 14 September 2026; its DOI will be added when available. Publication dates distinguish online-first release from issue dates where applicable.

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Keep the conversation going

From a paper to a collaboration.

Interested in device–vessel suitcordance, preclinical device evaluation, intravascular imaging or AI? Get in touch.